Smoking among American teenagers has continued to decline, reaching the lowest rate on record last year, as more and more of them experiment with vaping. These opposite trends seem inconsistent with warnings that the rising popularity of e-cigarettes will encourage consumption of the real thing. Still, it’s possible that the smoking rate among teenagers would be falling even faster if e-cigarettes had never been introduced. A study reported in the journal Tobacco Control last week provides ammunition for those who are inclined to think that’s the case. But contrary to what you may have read, it does not actually show that vaping leads to smoking.

Source: CDC survey data

Source: CDC survey data

The researchers, led by Thomas Wills, a social psychologist at the University of Hawaii Cancer Center, surveyed about 2,300 ninth- and 10th-graders, once in 2013 and again a year later. They found that students who in 2013 said they had never smoked were nearly three times as likely to report smoking in 2014 if they had tried e-cigarettes at the time of the initial survey. “We found that e-cigarettes had a risk-promoting effect for onset of smoking,” Wills et al. write. “While some of the transition to dual use was attributable to other variables that are correlated with e-cigarette use (e.g., ethnicity and rebelliousness), the effect of e-cigarettes for onset of smoking was independent of these variables.”

Although the researchers talk about the “onset of smoking,” the measure they used was whether subjects had tried conventional cigarettes at all. It’s not clear how many of those who had will ever be regular cigarette smokers. More important, the “risk-promoting effect” to which Wills and his colleagues refer is actually an association, and it’s not clear whether it represents a cause-and-effect relationship.

There are reasons why some teenagers try e-cigarettes while others do not, and those same factors—which could be related to personality, social circumstances, or tastes and preferences—may explain why those teenagers are also more likely to try conventional cigarettes. Wills and his colleagues tried to rule out alternative explanations for the association between vaping and smoking by controlling for several possible confounding variables, including demographic characteristics and measures of rebelliousness, sensation seeking, and parental support and monitoring. But it’s impossible to precisely measure and control for every variable that distinguishes teenagers who experiment with e-cigarettes from those who don’t.

Having assumed an effect that may not exist, Wills et al. suggest a couple of ways in which vaping could lead to smoking. “The reasons for the effect of e-cigarette use on transition to smoking remain to be clarified, but plausible hypotheses have been suggested,” they write. “One is that some e-cigarettes mimic the look and feel of cigarettes, and the inhaling and exhaling of e-cigarette aerosol produces some of the same sensory experiences as smoking a cigarette. This similar experience may contribute to an inclination towards trying cigarette smoking. Additionally, nicotine exposure via e-cigarettes, even at lower levels, may sensitise adolescents to its effects. If adolescents begin to experience mild physiological effects from nicotine they may be inclined to shift to cigarettes in order to get a bigger ‘kick.’”